Analysis of eligibility criteria representation in industry-standard clinical trial protocols
نویسندگان
چکیده
منابع مشابه
Patterns of Clinical Trial Eligibility Criteria
Medical research would benefit from automatic methods that support eligibility evaluation for patient enrollment in clinical trials and design of eligibility criteria. In this study we addressed the problem of formalizing eligibility criteria. By analyzing a large set of breast cancer clinical trials we derived a set of patterns, that capture typical structure of conditions, pertaining to synta...
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The amount of time and money required to screen patients for clinical trial and guideline eligibility presents the need for an automated screening process to streamline clinical trial enrollment and guideline implementation. This paper introduces an ontology-based approach for defining a set of patterns that can be used to represent various types of time-relevant eligibility criteria that may a...
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BACKGROUND We consider the user task of designing clinical trial protocols and propose a method that discovers and outputs the most appropriate eligibility criteria from a potentially huge set of candidates. Each document d in our collection D is a clinical trial protocol which itself contains a set of eligibility criteria. Given a small set of sample documentsD',|D'|≪|D|, a user has initially ...
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Various search engines are available to clinical trial seekers. However, it remains unknown how comprehensible clinical trial eligibility criteria used for recruitment are to a lay audience. This study initially investigated this problem. Readability of eligibility criteria was assessed according to (i) shallow and lexical characteristics through the use of an established, generic readability m...
متن کاملGenerating Medical Logic Modules for Clinical Trial Eligibility Criteria
Clinical trials are an important part of modern medical research, however the effort required to find candidates for participation in such trial is significant. With the increasing prevalence of electronic medical records, automated or semi-automated solutions become feasible. We present an semi-automated approach for determining clinical trial eligibility based on information available in an e...
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ژورنال
عنوان ژورنال: Journal of Biomedical Informatics
سال: 2013
ISSN: 1532-0464
DOI: 10.1016/j.jbi.2013.06.001